Manipulation of the endocannabinoid
system by a general anaesthetic
by
Di Marzo V.
Endocannabinoid Research Group,
Istituto di Chimica Biomolecolare,
Consiglio Nazionale delle Ricerche,
Via Campi Flegrei 34,
Comprensorio Olivetti, Fabbr 70,
80078 Pozzuoli (Napoli), Italy.
Br J Pharmacol. 2003 Jul;139(5):885-6
ABSTRACTAn article appearing in this issue of the British Journal of Pharmacology shows for the first time that the general anaesthetic propofol inhibits one of the enzymes catalysing endocannabinoid hydrolysis and inactivation, the fatty acid amide hydrolase, thereby enhancing the brain levels of anandamide and 2-arachidonoylglycerol in mouse brain. The authors provide evidence that this effect of propofol underlies part of the sedative effects of this compound. The importance of these findings in the light of the likely role of the endocannabinoid system in the control of sleep-wake cycles, and of the possibility of developing therapeutic drugs from substances that manipulate endocannabinoid levels, is discussed.THC
Bliss
Anandamide
Just say know
Tolerant mice
Endocannabinoids
Stoned as a newt?
The nectar of delight
Stoned chocaholics?
Cannabinoid receptors
Endocannabinoid hydrolases
Anaesthesia and anaesthetics
Endocannabinoids/endocrine system
Endocannabinoids and synaptic signalling01 02 03 04 05 06 07 08 09 10 11 12 13 14 15
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