Role of endocannabinoid system in mental diseases
by
Manzanares J, Uriguen L, Rubio G, Palomo T.
Servicio de Psiquiatria y Unidad de Investigacion,
Hospital 12 de Octubre
Edificio Materno-Infantil,
Planta 6a, 613-A, Avenida de Cordoba s/n.
28041 Madrid, Spain.
jorgemr@h12o.es
Neurotox Res. 2004;6(3):213-24
ABSTRACTIn the last decade, a large number of studies using Delta(9)-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid receptor activation. Cannabis has been historically used to relieve some of the symptoms associated with central nervous system disorders. Nowadays, there are anecdotal evidences for the use of cannabis in many patients suffering from multiple sclerosis or chronic pain. Following the historical reports of the use of cannabis for medicinal purposes, recent research has highlighted the potential of cannabinoids to treat a wide variety of clinical disorders. Some of these disorders that are being investigated are pain, motor dysfunctions or psychiatric illness. On the other hand, cannabis abuse has been related to several psychiatric disorders such as dependence, anxiety, depression, cognitive impairment, and psychosis. Considering that cannabis or cannabinoid pharmaceutical preparations may no longer be exclusively recreational drugs but may also present potential therapeutic uses, it has become of great interest to analyze the neurobiological and behavioral consequences of their administration. This review attempts to link current understanding of the basic neurobiology of the endocannabinoid system to novel opportunities for therapeutic intervention and its effects on the central nervous system.THC
Bliss
URB597
Anandamide
Just say know
Tolerant mice
Endocannabinoids
Stoned as a newt?
The nectar of delight
Stoned chocaholics?
Cannabinoid receptors
Endocannabinoid hydrolases
Endocannabinoids and synaptic signalling01 02 03 04 05 06 07 08 09 10 11 12 13 14 15
Refs
MDMA
HedWeb
Future Opioids
BLTC Research
Utopian Surgery
Paradise-Engineering
The Hedonistic Imperative
When Is It Best To Take Crack Cocaine?
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family
