The mechanism of action of cannabis and cannabinoids
by
Scholten WK.
wk.scholten@planet.nl
Ned Tijdschr Geneeskd. 2006 Jan 21;150(3):128-31.
ABSTRACTThe effect ofcannabis can be explained on the basis of the function of the cannabinoid receptor system, which consists of CB receptors (CB1, CB2), endoligands to activate these receptors and an enzyme--fatty acid amidohydrolase--to metabolize the endoligands. The endoligands of the cannabinoid receptor system are arachidonic acid-like substances, and are called endocannabinoids. Indications exist that the body also contains arachidonic acid-like substances that inhibit fatty acid amido hydrolase. Various cannabinoids have diverse effects on the receptors, functioning as agonists, antagonists or partial antagonists, as well as affecting the vanilloid receptor. Many known effects ofcannabis can be explained on the basis of this mechanism of action as can the use ofcannabis in various conditions including multiple sclerosis, Parkinson's disease, glaucoma, nausea, vomiting and rheumatoid arthritis.THC
Bliss
Aerosol
Memory
Anandamide
Just say know
Tolerant mice
Forgetful rodents
Endocannabinoids
Stoned as a newt?
The nectar of delight
Stoned chocaholics?
Cannabis Abuse Disorder
Cannabis and schizophrenia
Cannabinoids/Parkinson's disease
Fatty Acid amide hydrolase (FAAH)01 02 03 04 05 06 07 08 09 10 11 12 13 14 15
Refs
HedWeb
Future Opioids
BLTC Research
Paradise-Engineering
The Hedonistic Imperative
MDMA: Utopian Pharmacology
When Is It Best To Take Crack Cocaine?
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family
