Co-distribution of the cannabinoid CB(1) receptor and the 5-HT transporter in the rat amygdale
by
Ashton JC, Darlington CL, Smith PF.
Department of Pharmacology and Toxicology,
School of Medical Sciences,
University of Otago Medical School,
University of Otago,
Dunedin, New Zealand.
Eur J Pharmacol. 2006 Mar 24;

ABSTRACT

Cannabis sometimes causes dysphoria rather than euphoria; however, evidence relating to the interaction between the cannabinoid and 5-hydroxtryptamine (5-HT) systems is limited, especially in areas of the brain such as the amygdale. Here we report that cannabinoid CB(1) receptors and 5-HT transporter proteins are co-distributed in the amygdale, suggesting the possibility that activation of cannabinoid CB(1) receptors might cause a reduction in 5-HT release, similar to its effect on other neurotransmitters, thereby resulting in dysphoria.

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