Neuromorphological background of cannabis addiction
by
Wenger T, Moldrich G, Furst S.
Department of Human Morphology and Developmental Biology,
Semmelweis University, Tuzolto u. 58,
P.O. Box 95, Budapest, Hungary
Brain Res Bull. 2003 Jul 15;61(2):125-8

ABSTRACT

The expression of central cannabinoid (CB(1)) receptors in tyrosine hydroxylase (TH) containing neurones was demonstrated. Co-localisation was present in different brain areas responsible for reward-related mechanisms. The immunohistochemical investigations have shown that co-localisation is present in parts of mesolimbic-mesocortical dopaminergic system like nucleus accumbens (Nacb), ventral tegmental area (VTA), in the striatum, pyriform cortex, respectively. The results suggest a functional role of CB(1) receptors in cannabis addiction by acting directly on reward-related structures.

CB1
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Tolerant mice
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Forgetful rodents
Endocannabinoids
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